Overview
CBCMT faculty members have obtained numerous intramural projects from VIT as well as various extramural projects from various funding agencies like DST, DBT, BRNS and other international collaborative projects.
Research Projects at CBCMT
CBCMT faculty members have obtained numerous intramural projects from VIT as well as various extramural projects from various funding agencies like DST, DBT, BRNS and other international collaborative projects.
RESEARCH PROJECTS
Extramural Projects
| S.No | Project Titles | Agency | Year | PI | Co-PI | Amount |
|---|---|---|---|---|---|---|
| 1. |
Hydrogel Loaded 3D-Printed Hybrid Bone Graft for Reconstruction of Segmental Bone Defect |
DST-SERB | 2021-22 | Dr. Amitkumar Jaiswal | – | ₹28,34,120/- |
| 2. |
Development of in vitro Tissue-Engineered Model for Giant Cell Tumor of Long Bones |
BRNS | 2020-21 | Dr. Amitkumar Jaiswal | – | ₹24,60,000/- |
| 3. | Investigation on the Mechanism of Mucoadhesion and Transcytosis of Microglial Exosomes and its Biomimetic Nanoconstructs for Nose-to-Brain Delivery of Peptide Therapeutics | DBT-Ramalingaswamy Re-entry Fellowship Grant | 2020-21 | Dr. Arunkumar Pitchaimani | – | ₹1,13,60,000/- |
| 4. | Bioactive, Three Dimensional Sponge-Type Silk-Silica Composite Scaffolds for Bone Tissue Engineering | DST-SERB | 2021-22 | Dr. Sushma Kumari | – | ₹23,68,000/- |
| 5. | Design, development, and surface engineering of additively manufactured low modulus coaxial porous Ti-6Al-4V GYVO (Gyroid and Voronoi) structures for orthopedic applications | TATA-VIT | 2021-22 | Dr. Geetha Manivasagam | – | ₹34,50,000/- |
| 6. | Low-cost paper based disposable sensor for CEA (Carcino Embryonic Antigen) detection for cancer screening | VIT | 2020-21 | Dr. Joseph Nathanael | – | ₹2,00,000/- |
| 7. | Molecularly imprinted polymers (MIPs) coated green synthesized carbon dots (CQDs) based nanocomposites as point of use (PoU) platform for the specific detection of heavy metal ions in water | VIT | 2020-22 | Dr. Arunkumar Palaniappan | – | ₹1,50,000/- |
| 8. | Natural Bone inspired design and 3D printing of bone implants | DBT | 2020-21 | Dr. Cheirmadurai Kalirajan | – | ₹10,80,000/- |
| 9. | Development of Alginate silver nanocomposite embedded with adipose derived stem cells for the healing of deep burn wounds | LSRB, DRDO | 2020-21 | Dr. Raunak Kumar Das (CO-PI) | – | ₹38,12,000/- |
| 10. | Four dimensional (4D) bioprinting of smart nanocomposite artificial bone ECM with shape memory and programmable therapeutic delivery functions | DBT Ramalingaswami Re-entry Fellowship | 2019-20 | Dr. Joseph Nathanael | – | ₹1,13,60,000/- |
| 11. | Ligand Targeted PROTAC Conjugates: Chemically Induced Degradation of Disease-causing Kinases by a PROteolysis TArgeting Chimera’s (PROTACs) coupled with tumor targeting Ligands | DST | 2019-20 | Prof. Loganathan Rangasamy | – | ₹36,04,832/- |
| 12. | Design and fabrication of 3D printed gold nanorods loaded vascularized conducting starch composite-based cardiac patch- An attempt to make an indigenous engineered cardiac patch | DST | 2019-20 | Dr. Arun Kumar Palaniappan | – | ₹27,37,372/- |
| 13. | Design, fabrication and testing of portable, high-sensitivity aptasensors for one-step viral diagnostics | DST | 2019-20 | Dr. Murugan Ramalingam | – | ₹16,94,000/- |
| 14. | Development of Porous Titanium based implants for osteoporotic bone by rapid manufacturing and its chemical and biomechanical evaluations | DST | 2014-15 | Dr. Geetha Manivasagam | – | ₹14,62,000/- |
| 15. | Study of the High Cycle Fatigue (HCF) Behavior of Beta Titanium Alloy Til 5-3 | DRDO | 2014-15 | Dr. Geetha Manivasagam | – | ₹13,51,000/- |
| 16. | Investigations on artificially produced urinary stones composed of natural materials | DST | 2006-07 | Dr. N. Arunai Nambiraj | – | ₹18,21,441/- |
| 17. | Targeted microRNA Based Gene SilencingTherapeutics: Exploiting the Synergy between Targeting Ligands and Cell-Penetrating Peptides | DBT Ramalingaswami Re-entry Fellowship | 2020-25 | Dr. Loganathan Rangasamy | – | ₹1,13,60,000/- |
| 18. | Liquid feedstack plasma sprayed nanostructured layers on 3D printed porous Ti6AI4V implants impregnated with stem cells in collagen hydrogel for accelerated osseointegration | Indo-Swedan | 2020-23 | Dr. Geetha Manivasagam | Dr. Arunkumar Palaniappan | ₹37,83,000/- |
| 19. | Functionalization of new titanium alloys after ECAP processing and surface treatment | BRICS | 2020-23 | Dr. Murugan Ramalingam | Dr. Geetha Manivasagam | – |
| 20. | Optimization of stem cell-laden smart biomaterials for 3D bio printing of human cornea | DST-RCN (Norway) | 2020-23 | Dr. Murugan Ramalingam | – | ₹45,54,268/- |
| 21. | Design and development of an affordable gait training device | DST | 2019-20 | Dr. Mohan Varma D. S. | – | ₹25,15,270/- |
| 22. | A Gradient Approach for Engineering Interfacial Tissue Constructs using mesenchymal stem cells suitable for Osteochondral therapy | DST | 2019-20 | Dr. Murugan Ramalingam | Dr. Geetha Manivasagam | ₹26,58,120/- |
| 23. | Enhancement of biocompatibility and wear resistance of orthopaedic beta titanium alloy Ti-35nb-7zr-5ta by nano-surface modification | CSIR | 2019-20 | Dr. Geetha Manivasagam | – | ₹5,27,000/- |
| 24. | Tumor specific inhibition of NF-kB: A potential gene therapy approach for treating Glioblastoma | DBT | 2018-21 | Dr. Dwaipayan Sen | – | ₹42,87,600/- |
| 25. | Engineering Superhemophobic nanostructured surfaces on superelastic Ni-free Ti based alloys for stent applications | Indo-German | 2018-19 | Dr. Geetha Manivasagam | – | ₹8,88,000/- |
| 26. | Effect of shot peening and laser shock peening on fatigue behavior Ti-15V-3Al-3Sn-sCr | ISRO | 2018-19 | Dr. Geetha Manivasagam | – | ₹18,66,000/- |
| 27. | Controlled drug delivery to prevent bacterial adhesion and enhace ossteoconduction of Ti alloys used in spinal application by tailoring the surface with nanopores | Indo-Austria | 2017-18 | Dr. Geetha Manivasagam | – | ₹6,48,500/- |
| 28. | Protection against neurodegenerative diseases through secreted trophic factors of human umbilical cord derived stromal cells. | – | 2018-20 | Dr. Durai Murugam Muniswami | Dr. Dwaipayan Sen | ₹19,20,000/- |
| 29. | Fibrous matrix-hydrogel double layered synthetic human skin substitute for full-thickness burn wounds. | DST | 2017-20 | Dr.Amit Kumar Jaiswal | Niroj Sahu and Dr.Arunai Nambiraj | ₹39,91,600/- |
| 30. | Potential neuroprotective effect of the delta opiod peptide | ICMR | 2017-20 | Dr Dwaipayan Sen | – | ₹27,24,500/- |
| 31. | Transplantation of MSC derived DA neurons promote functional Recovery in Amounts a murine PD model | DST | 2017-19 | Dr Venkatesh Katari | Dr Dwaipayan Sen | ₹19,20,000/- |
RESEARCH PROJECTS
VIT Funding
| S.No | Project Titles | Agency | Year | PI | Amount |
|---|---|---|---|---|---|
| 1. | Ligand Targeted PROTAC Conjugates: Chemically Induced Degradation of Disease-causing Kinases by a PROteolysisTArgetingChimera’s (PROTACs) Coupled with Tumor Targeting Ligands | VIT | 2020-21 | Prof. Loganathan Rangasamy | ₹1,50,000/- |
| 2. | Photodynamic Therapy using Red Fluorescent Graphene Quantum Dots | VIT | 2020-21 | Prof. Satyaprakash Ahirwar | ₹1,50,000/- |
| 3. | 3D printed tissue equivalent kidney phantom for urinary stone characterization | VIT | 2020-21 | Dr.N.Arunai Nambiraj | ₹1,50,000/- |
| 4. | Nanoengineered multifunctional cardiac patch for the treatment of myocardial infarction | VIT | 2020-21 | Dr.Arunkumar Palaniappan | ₹1,00,000/- |
| 5. | 3D bioprinting of vascularised liver tissue equivalent using stem cells and nano gels | VIT | 2019-20 | Dr. Murugan Ramalingam | ₹1,00,000/- |
| 6. | Development of a biomaterial scaffold as an in vitro model of giant cell tumour of long bones | VIT | 2018-19 | Dr. Amit Kumar Jaiswal | ₹2,00,000/- |
| 7. | A Gradient Approach for Engineering Interfacial Tissue Constructs using Mesenchymal Stem Cells suitable for Osteochondral Therapy | VIT | 2018-19 | Dr. Murugan Ramalingam | ₹1,50,000/- |
| 8. | Novel peptide-modified chitosan-PVA-HA electrospun matrix system to promote angiogenesis with antibacterial effect for skin wound healing applications | VIT | 2018-19 | Dr. Sunita Nayak | ₹1,50,000/- |
| 9. | Development of Tissue Engineered Scaffolds for Reconstruction of Giant Cell Tumor Resected Bone Defects | VIT | 2017-18 | Dr. Amit Kumar Jaiswal | ₹1,50,000/- |
| 10. | Cytomodulin functionalized poly chitosan-hyaluronic acid nanofiber based skin graft substitute doped with Neem oil nano formulations: In vitro and in vivo investigation of its angiogenic and antimicrobial effects for wound healing applications | VIT | 2017-18 | Dr. Sunita Nayak | ₹1,50,000/- |
| 11. | Engineering Superhemophobic nanostructured surfaces on superelastic Ni-free Ti based alloys for stent applications | VIT | 2017-18 | Dr. Geetha Manivasagam | ₹1,00,000/- |
| 12. | Cis-Dichlorodiaminoplatinum (II), Antineoplastic Drug, Conjugated with Resorbable Polymer Repurposed as Antibiofilm agent coupled with Antibiotics for in situ Management of Diabetic Osteomyelitis: In vitro and rodent model based study | VIT | 2017-18 | Dr. Debasish Mishra | ₹1,50,000/- |
| 13. | VAPOUR-LIQUID EQUILIBRIUM OF NITRIC ACID-WATER SYSTEM USING IONIC LIQUIDS | VIT | 2017-18 | Dr. V. P. Gurumoorthy | ₹1,00,000/- |
| 14. | Indigenisation of porous Ti-6Al-4V implant for bone fracture | VIT | 2016-17 | Dr. Geetha Manivasagam | ₹3,00,000/- |
| 15. | Inferring the potential positive effect | VIT | 2016-17 | Dr. Dwaipayan Sen | ₹2,00,000/- |
| 16. | Induction of EMT in primary oral epithelial cells and HaCaT cells through exosomes derived from HPV infected cell lines | VIT | 2016-17 | Dr. Raunak Kumar Das | ₹2,00,000/- |
| 17. | Transcriptome/miRNAome signature change in delta opioid agonist induced survival of murine mesenchymal stem cells (MSCs) ex vivo- implications in cardiac regeneration following myocardial infarction | VIT | 2016-17 | Dr. Dwaipayan Sen | ₹3,00,000/- |
| 18. | Effect of shot peening and Laser/shock peening on Low Cycle Fatigue behaviour of Ti-6Al-4V(Grade 5) alloy and Ti-6Al-4V-ELI /Grade 23 Alloy | VIT | 2016-17 | Dr. Geetha Manivasagam | ₹2,80,000/- |
Nothing Beats Good Education For The Betterment Of A Student’s Future
With this addition, centre is better positioned to fabricate 3D organoids, tissue mimics, which will also be one of the key focus areas in coming years.The ongoing projects of the center are funded by both national and international funding agencies. The center also has a strong research collaboration with scientists from leading research laboratories across the globe.